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认知催眠疗法减轻胃癌化疗患者癌因性疲乏的疗
作者:中糖院 时间:2020-04-06 15:33:36 浏览:187

认知催眠疗法减轻胃癌化疗患者癌因性疲乏的疗效观察

董秀红

认知催眠疗法减轻胃癌化疗患者癌因性疲乏的疗

    

潍坊医学院附属医院消化科,山东 潍坊 261031

收稿日期:2016-05-26 ;网络出版时间:2016-06-06 12:00:00

通讯作者:董秀红。E-mail:dongxhong@126.com

摘要: 目的 探讨认知催眠疗法在减轻胃癌患者化疗所致癌因性疲乏中的应用效果。 方法 将60例符合标准的胃癌化疗患者随机分为研究组和对照组,每组30例。2组患者均施行FOLFOX4方案化疗。于化疗第1天开始研究组给予认知催眠疗法,对照组给予常规健康教育,1次/d,每个化疗周期2次。于每周期化疗前、化疗结束后第5天和全部化疗结束后2个月分别评价2组患者的FACIT-F得分及TNF-α、IL-1β、IL-6水平。 结果 化疗前2组患者疲乏程度相当,FACIT-F评分无统计学差异(P>0.05)。化疗后2组FACIT-F评分呈下降趋势,对照组下降更明显,差异有统计学意义(P<0.01);2组TNF-α、IL-1β、IL-6水平呈增加趋势,对照组增加更明显,差异有统计学意义(P<0.01)。化疗结束后2个月研究组FACIT-F评分及TNF-α、IL-1β、IL-6水平仍高于对照组,差异具有统计学意义(P<0.05)。 结论 认知催眠疗法能够降低TNF-α、IL-1β、IL-6水平,明显改善胃癌化疗患者癌性疲劳,有望成为化疗所致癌因性疲乏的一种新的辅助治疗手段。

关键词: 认知催眠疗法    癌因性疲乏    化疗    胃癌    

Effect of cognitive-behavioral therapy plus hypnosis in controlling cancer-related fatigue in gastric cancer patients receiving chemotherapy

DONG Xiuhong

认知催眠疗法减轻胃癌化疗患者癌因性疲乏的疗

    

Department of Gastroenterology, Affiliated Hospital of Weifang Medical University, Weifang 261031, Shandong, China

Abstract: Objective To explore the effect of cognitive-behavioral therapy plus hypnosis to reduce cancer-related fatigue (CRF) in gastric cancer patients undergoing chemotherapy. Methods A total of 60 gastric cancer patients undergoing chemotherapy were randomly assigned to 2 groups: experimental group (n=30) and control group (n=30). All patients adopted FOLFOX4 chemotherapy scheme. On day 1 of the treatment, the experimental group underwent cognitive-behavioral therapy plus hypnosis, while the control group was provided with routine health education. The intervention was performed once a day, twice in each chemotherapy cycle. The score of FACIT-F, levels of TNF-α, IL-1β and IL-6 were measured at baseline, 5 days and 2 months after chemotherapy. Results There were no differences between the 2 groups in fatigue and FACIT-F score before chemotherapy (P > 0.05). After chemotherapy, the FACIT-F scores of both groups decreased, and the control group had larger margin of decrease (P < 0.01); the levels of TNF-α, IL-1β and IL-6 in both groups increased, and the control group had a larger margin of increase (P < 0.05). Two months after chemotherapy, the experimental group had higher FACIT-F score and higher levels of TNF-α, IL-1β and IL-6 than the control group (P < 0.01). Conclusion Cognitive-behavioral therapy plus hypnosis is able to reduce TNF-α, IL-1β and IL-6 levels, and control fatigue in patients undergoing chemotherapy for gastric cancer. Therefore, it may serve as a promising auxiliary treatment for chemotherapy.

Key words: Cognitive-behavioral therapy plus hypnosis    Cancer-related fatigue    Chemotherapy    Gastric cancer    

癌因性疲乏(cancer-related fatigue,CRF)是一种持续性的主观疲劳感觉,与癌症或癌症治疗相关而与近期的活动无关,并且干扰正常生活。CRF长期困扰着癌症患者,贯穿于疾病的治疗前、治疗中、治疗结束后,直至患者生命终结期。CRF发生率高达30%~99%,严重影响了患者的生活质量[]。近年研究表明,认知催眠疗法能够减轻癌性疼痛等慢性疼痛[],但认知催眠疗法在减轻胃癌化疗患者癌因性疲乏中的应用情况未见相关报道。本研究通过认知催眠疗法在胃癌化疗患者中的应用,初步评价其减轻患者癌因性疲乏的效果,旨在为化疗患者的癌因性疲乏治疗探索新模式。

1 资料与方法 1.1 研究对象